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Frequently Asked Questions

Find the answers to your most commonly asked questions below.

Q: What are transfer factors?

A: Transfer factors aren’t vitamins, minerals, or herbs—substances that add nutrients to the body. Transfer factors are molecules that actually transfer immune memory and knowledge from one immune system to another.

Q: When were transfer factors discovered?

A: In 1949, Dr. H. Sherwood Lawrence, a New York University immunologist, determined that an immune response could be transferred from a donor to a recipient through a white blood cell extract. He concluded that the extract contained a factor capable of transferring the donor’s immunity information to the recipient and named the substance transfer factor.

In 1998, 4Life Founders David and Bianca Lisonbee licensed the patent to extract transfer factors from cow colostrum. The introduction of 4Life Transfer Factor® Classic opened the door to a new category of immune system support products. 4Life’s commitment to transfer factor research has progressively raised the standard for modern-day immune system supplementation.

Q: What research has been done on transfer factors?

A: In the 50 years since Dr. Lawrence’s pioneering work on transfer factors, an estimated $40 million has been spent researching transfer factors and hundreds of scientific papers have been published documenting their effectiveness.

Recent independent studies report that 4Life Transfer Factor and 4Life Transfer Factor Plus Tri-Factor Formulas boost Natural Killer cell activity a remarkable 283% and 437%* when your body needs it.

Q: How does 4Life Transfer Factor support my immune system?

A: Transfer factors are some of the most unique molecules in your body. They carry important messages to immune cells all over the body, helping them fight harder and more effectively to keep you well.

Transfer factors provide intelligence to the immune system in three very important ways:
Recognize. Transfer factors help immune cells identify invading germs and other problems more quickly.
Respond. Transfer factors help speed up the immune system’s response to an invader after it’s been identified.
Remember. Transfer factors lend a hand in remembering the specific makeup of each germ your immune system encounters, so the next time it comes around, your body knows exactly what it is, and what to do.

Q: Why does my immune system need support?

A: When your immune system works hard, you’re able to work and play hard. But when immune system function is impaired by too little sleep, environmental hazards, poor diet, or a high-stress lifestyle, it can’t do its job. You should care about your immune system, because it cares for you.

Q: How can 4Life Transfer Factor support healthy energy levels?

A: 4Life Transfer Factor supports healthy energy levels by promoting the effectiveness of your immune system. When your immune system is working as it should, you have plenty of energy to do the things you love. Plus, the more energy you have, the faster your body responds to any new problem it encounters.

Q: If I eat healthy foods, why do I need 4Life Transfer Factor?

A: Healthy foods provide your body with important nutrients to help keep it strong. Immune cells definitely need this nutrition, but they also need education. That’s what 4Life Transfer Factor provides—the education and information to help immune cells know what they should be doing to keep the immune system running at peak performance.

Q: What is Transferceutical™ Science?

A: Transferceutical Science encompasses the research and development of products that educate the immune system to recognize, respond to, and remember potential threats. Transferceutical Science and Products were pioneered by 4Life Research.

Q: How is 4Life Transfer Factor different from other products?

A: The biggest key to overall immune system health is balance—boosting when needed and calming down when needed. Almost all immune system products on the market today (vitamins, minerals, and herbs) have one thing in common: they provide temporary nutrition. However, the best long-term solution to an active, balanced immune response is information.

The way that 4Life Transfer Factor works with your body's immune system is completely unique. It teaches your immune system to recognize, respond to, and remember potential invaders. Looking beyond nutrition to information is a profound paradigm shift, and 4Life Transfer Factor is the only product available that leverages this powerful paradigm.

4Life Transfer Factor Products were tested against other products advertised to increase immune function. 4Life’s products showed an increase in Natural Killer cell activity by up to 437 percent*, a far superior result to other products tested.

Q: Where does 4Life Transfer Factor come from?

A: Nature has perfected a way to help keep its young healthy. A mother passes on vital immune know-how (gathered from her own experiences) in the first critical days of life. Mammals pass on this information through the mother’s first milk, or colostrums, while other animals pass it through the egg. Transfer factors and nanofraction molecules are important components of this education acting as nature’s first supplements.

Using patented and patent-pending processes, 4Life extracts transfer factors from cow colostrum and chicken egg yolks to provide a wide range of immune system support. 4Life obtains nanofraction molecules from cow colostrum using a nano filter.

Chickens and cows live outside, leaving them exposed to a variety of germs, which their immune systems must battle in order to stay healthy. Both transfer factors and nanofraction molecules can be safely transferred to humans, making cow colostrum and chicken egg yolk excellent sources for immune system support.

Q: What is NanoFactor™?

A: NanoFactor is 4Life’s exclusive extract of nanofraction molecules from cow colostrum. NanoFactor provides essential intuition to the immune system, so immune cells know when to act, how to act, and when to rest.

Q: What is Tri-Factor® Formula?

A: 4Life Transfer Factor Tri-Factor Formula brings together the intelligence of 4Life Transfer Factor and the intuition of NanoFactor, to regulate, boost, and balance the immune system… according to what your body needs.

Q: Does 4Life have patents for their transfer factor products?

A: Yes. 4Life has obtained U.S. patents for its transfer factor products from cow colostrum and chicken egg yolks. The extraction process for transfer factors from chicken egg yolks is protected by U.S. patent 6,468,534; exclusive combination techniques for transfer factors from cow colostrum and chicken egg yolks are protected by U.S. patent 6,866,868.

Q: What is RioVida®?

A: 4Life Transfer Factor RioVida Tri-Factor Formula is the only transfer factor drink in the world. It combines Tri-Factor Formula with powerful antioxidant fruit juices, including açaí, blueberries, pomegranates, elderberries, and purple grapes. The fruits found in RioVida support healthy cardiovascular, digestive, urinary, and immune system functions.

Q: What is Targeted Transfer Factor®?

A: Using a patented process (US Patent 6,468,534), 4Life extracts transfer factors from chicken egg yolks. These transfer factors are then focused to benefit specific body systems. 4Life’s Targeted Transfer Factor line includes products for the cardiovascular system, endocrine/metabolic systems, male prostate health, female reproductive system and breast health, and brain.

Q: I don't like swallowing capsules. How else can I take 4Life Transfer Factor?

A: 4Life Transfer Factor comes in a variety of delivery systems to make it easy to get daily immune system support.

4Life Transfer Factor RioVida Tri-Factor Formula: 4Life Transfer Factor RioVida is the only transfer factor drink in the world. It combines Tri-Factor Formula with powerful antioxidant fruit juices.

4Life Transfer Factor Immune Spray: 4Life Transfer Factor Immune Spray is a great-tasting formula that combines the anti-bacterial properties of colloidal silver with the immune power of Transfer Factor XF®.

4Life Transfer Factor Chewable Tri-Factor Formula: 4Life Transfer Factor Chewable Tri-Factor Formula comes in a chewable tablet and lets you enjoy the health benefits of Tri-Factor Formula.

4Life Transfer Factor Kids: 4Life Transfer Factor Kids contains Transfer Factor E-XF™, plus vitamins and minerals that kids need for proper growth and good health.

enummi® Personal Care products: The 4Life enummi Personal Care line includes products with time-tested ingredients—including 4Life Transfer Factor—to support healthy skin. Choose from Gentle Facial Cleanser, Refreshing Toner, Protective Moisturizer, Night Recovery Cream, Restoring Eye Cream, Intensive Body Lotion, Lite Body Lotion, and Toothpaste.

4Life Transfer Factor RenewAll™: 4Life Transfer Factor RenewAll blends healthful ingredients in an easy-to-apply topical gel that supports the skin's natural immune defenses and the body's natural healing process.

Q: How can I learn more about 4Life Transfer Factor?

A: There are many resources available to help you learn more about 4Life Transfer Factor. Speak with the person who referred you to this site to learn more.

Q: How can I share 4Life Transfer Factor products with other people?

A: 4Life offers a financial opportunity just as rewarding as its innovative products. To find out more about how you can share these products with others, please visit www.4life.com.


*Test results obtained from independent NK cell studies conducted by Dr. Anatoli Vorobiev, head of Immunology, at the Russian Academy of Medical Science. The blind studies tested 4Life Transfer Factor E-XF (the primary ingredient in Tri-Factor Formula) and other immune system products.

Who Can Use Transfer Factor?

People of all ages can use transfer factor. Transfer factor was, in fact, designed by nature for newborns. People wishing to give transfer factor to infants and children under age 12 should work closely with a medical professional on deciding what dose to take. Typically, children do well with doses half that of the adult/label dose. Infants would require somewhat less. While there is no known toxicity to transfer factor, picking doses for younger children and infants should be done with prudence.

Who Needs Transfer Factor?

Anyone—healthy or diseased, with a few exceptions—benefits from regular transfer factor supplementation. The use of transfer factor has resulted in no reports of serious adverse reactions, even when clinically administered in doses in excess of normal for prolonged periods.

Those with specific ailments also benefit. Numerous studies have shown the effectiveness of transfer factor in eliminating or aleviating symptoms of herpes, chronic fatigue syndrome, epstein barr, hepatitis, secondary infection due to AIDS, candida, cancer and many other disorders. Studies have also shown than continual use provides the greatest benefit with maximum immune activity occuring 24 to 48 hours after initial dosing.

The need for transfer factor as an adjunct to better health stems from the growing awareness that prevention is the best source of treatment. With the increasing risks of antibiotic resistance and significant health threats, such as SARS, the medical community increasingly turns to the inherent concept of vaccines—prevention.

Transfer factors are akin to vaccines. But, rather than expose the patient’s immune system to the actual disease or a deactivated version of the same, transfer factors expose the patient’s immune system to the memory of a health threat—whether foreign or native—and the knowledge of how to best respond to protect itself.

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  • Should I take Transfer Factor™ or Transfer Factor™ Plus?

    If an individual should choose to use Transfer Factor™, their immune system may be supported in ways that it otherwise would not. Transfer factors work as instructors to the different members of the immune system. This instruction assists the function of the immune system in recognizing and fighting outside threats to your health. Transfer factors are immune modulators, which means that they are able to support healthy immune function by an Inducer Factor as well as a Suppressor Factor. In addition, an independent study showed that 4Life™'s Transfer Factor™ was shown to increase the Natural Killer cell (NK)activity by more than 100%. This is an important discovery in that NK cells carry the immune messaging cytokines, which direct battle with outside threats. When NK cell count is increased the immune system is working more effectively.

    Transfer Factor Plus™ is different from Transfer Factor™ in that it has additional ingredients. These ingredients include thymic proteins, cordyceps, IP-6, maitake mushrooms, beta glucan, zinc, and shiitake mushrooms that help initiate a stronger stimulating immune response than that of Transfer Factor™. Transfer Factor Plus™ strengthens both the innate immune system (the immune information an individual is born with) and the adaptive immune system (the immune information an individual's immune system has obtained throughout life). For your individual condition, either or both of these products may be of benefit to you because of its supporting and strengthening. If you choose to use these products, please consult your physician to make sure there will be no complications or interactions associated with your current state of health. Greater information and detail is available through Dr. William J. Hennen's booklets entitled Natural Immune Booster: Transfer Factor and Enhanced Transfer Factor

  • Is Transfer Factor™ Casein and Gluten free?

    Yes, in preparing Transfer Factor™ the large molecular proteins are removed, including casein and antibodies. Milk allergies are caused by the large proteins in milk, primarily casein and to a lesser extent antibodies.

    Gluten is another extracted protein and is predominately isolated from wheat, rye and barley. Because Transfer Factor XF is extracted from colostrum, gluten is not found in Transfer Factor™. 

  • Can you take transfer factors from one group of people and give them to another group of people?

    This process is how Dr. Lawrence discovered transfer factors. He took the white blood cells (leukocytes) from a previously infected tuberculosis patient, who has regained their health, and injected these white blood cells into a recently infected patient. The white blood cells from the "old" TB patient contain information on how the immune system fights against the disease and transferred this information to the "new" patient. 

  • Is Transfer Factor™ effective on large animals such as horses? If so, what is the suggested serving?

    Yes, Transfer Factor™ can be given to animals, including horses. TF Pets™ is available for canines and felines, but regular Transfer Factor™ can be taken by any animal. Remember when you are calculating serving size for animals that they have a much more "heroic" and responsive immune system. Animals, especially the grazers, are much more immunologically responsive and can get by with less Transfer Factor™ per pound. The immune system has a way of amplifying the signal. Serving sizes for larger animals do not always correspond to weight entirely, especially when you are dealing with grazers. Start your animal on a minimal amount and continue to increase the serving over time, if necessary. 

  • Why do we need to use Transfer Factor™ if we received immune information when we were infants?

    The transfer factors we received as infants are just purposeful as those available in Transfer Factor™. As infants, mother's colostrum gave immune information while our immune systems were not fully developed, but the transfer factors were absorbed into the bloodstream and eventually were used up to become part of the functioning immune system, consisting of lymphocytes, natural killer cells, macrophages, etc. The information provided at birth was to work against the specific threats experienced by your mother at that time; after years of life new threats to the immune system exist. By using oral transfer factor we are providing the same type of immune information we received at birth. 

  • How does Transfer Factor™ react to heat?

    Long-term exposure to high temperatures can degrade potency and possibly neutralize Transfer Factor™ activity. Transfer Factor should be stored in a cool, dry environment. 

  • Can people who are lactose intolerant use Transfer Factor™?

    Yes. The large proteins, such as lactose, are filtered out during the extraction process. Are transfer factors made of sugars, proteins or fats? Isolated transfer factors have been determined to be a chain of small peptides consisting of 44 amino acids. Amino acids are the building blocks of proteins. 

  • Is transfer factor good only for newborns?

    Transfer factor is good for everyone who needs an extra immune boost. The three groups who are most in need of immune strengthening are the young, the old, and anyone under stress. Almost all of us fall into one of these categories. We often talk of the baby-boom generation. Most of these people are at an age where already their immune systems are becoming lax. Transfer factor is a way to boost a lagging immune system. 

  • If transfer factor is so effective, then why hasn't the pharmaceutical industry jumped on it?

    I think that is exactly what we are seeing in many countries, notably China, Czechoslavakia, Germany, Hungary, Poland, and Japan. In the US, transfer factor has had an interesting history. The idea of transfer factor flies in the face of conventional immunology. In the 1950's, antibiotics were the golden child of medicine, followed in the 60's by steroids like cortisone for inflammation and the synthetic steroid hormones like ethinyl estrogen and progestin that were used to create the birth control pill. After an initial delay, transfer factor hit its heyday in the 70's and early 80's. Results, however, were inconsistent as researchers dove in sometimes with more enthusiasm than skill. The key feature that was missing in these investigations was a dependable assay technique for quality control of the product. The quality control issue was not resolved until the mid 1980's. Given that transfer factor is not a single entity, the pharmaceutical companies had fits trying to purify the material without losing efficacy. This attempted force-fit into the single-entity, single-function drug dogma was disastrous. The next issue that slowed transfer factor research is the age-old issue of funding. When AIDS hit the popular press, politicians shifted funding into AIDs research, but with focus on finding the cause and then finding a drug that would cure AIDs. The work of a few, dedicated, but under-funded researchers and the inability of the mainstream medical-pharmaceutical industry have combined to again focus attention on transfer factor as one of the few modalities that is effective against diseases of viral origin. 

  • Are there reasons why we haven't seen transfer factor as a food supplement before now?

    Yes, there are two doors that recently have opened that allow transfer factor to be effectively marketed now. The first door to open was the passage of the DSHEA (Dietary Supplement Health and Education Act) in 1994. The provision for structure-functions claims allows the story of transfer factor to be told without jeopardizing its status as a nutritional supplement. The second is technical. Transfer factor was definitely an idea way ahead of its time and it had to wait for technology to catch up. The processing methods that allow for large scale extraction of transfer factor have only recently been perfected, and a commercial product has only been available for the last three years. 

  • Is Transfer Factor™ FDA approved?

    Foods and dietary supplements are not approved per se by the FDA. Food supplements derived from milk would certainly fall under the category of Generally Recognized As Safe (GRAS). 

  • Is Transfer Factor™ safe?

    YES. Researchers have given huge doses of transfer factor to volunteers in an attempt to trigger some sort of adverse reaction. No negative side effects were observed, even with massive doses. 

  • Is Transfer Factor™ safe for infants?

    Colostral transfer factor was designed by nature for newborns. Removal of the milk allergens and lactose leaves the essence of the immunologic information in the form of transfer factor. 

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